Sigmund Freud

popularized the absorption of cocaine crystals (prepared by the Merck Laboratories) through the nasal mucous membrane

The nasal absortion of a quantity of 60 mg dispensed through the nasal mucosa, produces a general increase of body energy.
Metabolism accelerates in proportion to the dose, just as does  the physical, intellectual activities and rising emotional tone.
Cardiac frequency and blood pressure also rise slightly. Respiratory frequency and volume are increased assuring a greater oxygen intake.
Hunger and tiredness sensations disappear.